Introduction | Data structure and formula interface | Classical designs and the formula interface | Marginal distributions and relative effects | Weighted and unweighted relative effects | Hypotheses H0F and H0p | A one-factor longitudinal example | A factorial longitudinal example | Missing observations | Dependent replicate measurements | Term-specific effect plots | Test statistics and multiple contrasts | [\widehat | [\widehat | [T_\ell | A real-data example: shoulder tip pain | Interpreting the output | Practical recommendations